BIG Breast International Group
We will find a cure for breast cancer through global research and collaboration.


The Study Of Letrozole Extension (SOLE) study is a phase III trial evaluating the role of continuous letrozole versus intermittent letrozole following 4 to 6 years of prior adjuvant endocrine therapy for postmenopausal women with hormone-receptor positive, node-positive early stage breast cancer.

Coordinating group: IBCSG

Patients accrual
Start date: November 2007
Closure date: October 2012
Target nr. of patients: 4800
Final accrual: 4884

Reason for closure: reached targed accrual Identifier: NCT00553410

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Breast International Group (BIG)-aisbl Blvd de Waterloo 121 B-1000 Brussels | Belgium VAT BE 0468 176 240